|
|
(1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+ <=> 3,4-dihydroxybenzoate + CO2 + NADH
|
1.3.1.53
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
|
–
|
MK
|
|
BRENDA:
BR1201
KEGG:
R01633
MetaCyc:
1.3.1.53-RXN
|
|
|
|
H+ + 4,5-Dihydroxyphthalate <=> CO2 + 3,4-dihydroxybenzoate
|
4.1.1.55
4,5-dihydroxyphthalate decarboxylase
|
–
|
K
|
|
BRENDA:
BR315
KEGG:
R01635
MetaCyc:
45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN
|
|
|
|
H+ + 3,4-dihydroxybenzoate <=> CO2 + catechol
|
4.1.1.59
gallate decarboxylase
4.1.1.61
4-hydroxybenzoate decarboxylase
4.1.1.63
protocatechuate decarboxylase
|
–
–
–
|
K
|
|
BRENDA:
BR324
KEGG:
R00822
MetaCyc:
PROTOCATECHUATE-DECARBOXYLASE-RXN
|
|
|
|
H+ + 3,4-dihydroxyphthalate <=> CO2 + 3,4-dihydroxybenzoate
|
4.1.1.69
3,4-dihydroxyphthalate decarboxylase
|
–
|
MK
|
|
BRENDA:
BR3362
KEGG:
R01634
MetaCyc:
34-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN
|
|
|
|
4-hydroxybenzoate + NADPH + O2 + H+ <=> 3,4-dihydroxybenzoate + NADP+ + H2O
|
1.14.13.2
4-hydroxybenzoate 3-monooxygenase
1.14.13.33
4-hydroxybenzoate 3-monooxygenase [NAD(P)H]
|
–
–
|
BMK
|
|
BRENDA:
BR36759
KEGG:
R01298
MetaCyc:
1.14.13.33-RXN;
4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN
|
|
|
|
4-hydroxybenzoate + NADH + O2 + H+ <=> 3,4-dihydroxybenzoate + NAD+ + H2O
|
1.14.13.2
4-hydroxybenzoate 3-monooxygenase
1.14.13.33
4-hydroxybenzoate 3-monooxygenase [NAD(P)H]
1.14.99.15
4-methoxybenzoate monooxygenase (O-demethylating)
|
–
–
–
|
K
|
|
BRENDA:
BR40422-a
KEGG:
R01296
MetaCyc:
1.14.13.33-RXN_WOP
|
|
|
|
3-hydroxybenzoate + O2 + NADPH + H+ <=> 3,4-dihydroxybenzoate + H2O + NADP+
|
1.14.13.2
4-hydroxybenzoate 3-monooxygenase
1.14.13.23
3-hydroxybenzoate 4-monooxygenase
|
–
–
|
MK
|
|
BRENDA:
BR40430
KEGG:
R01628
MetaCyc:
3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN
|
|
|
|
O2 + NADH + 4-Sulfobenzoate <=> sulfite + NAD+ + 3,4-dihydroxybenzoate
|
1.14.12.8
4-sulfobenzoate 3,4-dioxygenase
|
–
|
MK
|
|
BRENDA:
BR40439
KEGG:
R01636
MetaCyc:
4-SULFOBENZOATE-34-DIOXYGENASE-RXN
|
|
|
|
O2 + 3,4-dihydroxybenzoate <=> H+ + 4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde
|
1.13.11.8
protocatechuate 4,5-dioxygenase
|
–
|
MK
|
|
BRENDA:
BR40467
KEGG:
R01632
MetaCyc:
PROTOCATECHUATE-45-DIOXYGENASE-RXN
|
|
|
|
O2 + 3,4-dihydroxybenzoate <=> H+ + 3-carboxy-cis,cis-muconate
|
1.13.11.3
protocatechuate 3,4-dioxygenase
|
–
|
BMK
|
|
BRENDA:
BR40477
KEGG:
R01631
MetaCyc:
PROTOCATECHUATE-34-DIOXYGENASE-RXN
|
|
|
|
vanillic_acid + O2 + NADH + H+ <=> 3,4-dihydroxybenzoate + formaldehyde + NAD+ + H2O
|
1.14.13.82
vanillate monooxygenase
|
–
|
MK
|
|
BRENDA:
BR47607
KEGG:
R05274
MetaCyc:
RXN-10891
|
|
|
|
3-dehydroshikimate <=> 3,4-dihydroxybenzoate + H2O
|
4.2.1.118
3-dehydroshikimate dehydratase
|
–
|
BMK
|
|
BRENDA:
BR49127
KEGG:
R01627
MetaCyc:
DHSHIKIMATE-DEHYDRO-RXN
SABIO-RK:
1768
|
|
|
|
3,4-dihydroxybenzoate + Br- + O2 + NADPH + H+ <=> 3,5-dibromobenzene-1,2-diol + CO2 + H2O + NADP+
|
1.14.19.55
4-hydroxybenzoate brominase (decarboxylating)
|
–
|
|
|
BRENDA:
BR52354
KEGG:
R12018
MetaCyc:
RXN-19114
|
|
|
|
3,4-dihydroxybenzoate + Br- + O2 + NADPH + H+ <=> 3-bromo-4,5-dihydroxybenzoic_acid + H2O + NADP+
|
1.14.19.55
4-hydroxybenzoate brominase (decarboxylating)
|
–
|
M
|
|
BRENDA:
BR52355
KEGG:
R12019
MetaCyc:
RXN-19112
|
|
|
|
3,4-dihydroxybenzoate + holo-[aryl-carrier_protein] + ATP <=> 3,4-dihydroxybenzoyl-[aryl-carrier_protein] + AMP + diphosphate
|
6.2.1.62
3,4-dihydroxybenzoate---[aryl-carrier protein] ligase
|
–
|
|
|
BRENDA:
BR53042
MetaCyc:
RXN-19494
|
|
|
|
3,4-Dihydroxybenzaldehyde + O2 + H2O <=> H+ + 3,4-dihydroxybenzoate + H2O2
|
1.17.3.2
xanthine oxidase
1.2.3.1
aldehyde oxidase
1.2.3.9
aryl-aldehyde oxidase
|
–
–
–
|
|
|
BRENDA:
BS189338
MetaCyc:
RXN-8091
|
|
|
|
3,4-Dihydroxybenzaldehyde + NAD+ + H2O <=> 3,4-dihydroxybenzoate + NADH + H+
|
1.17.1.4
xanthine dehydrogenase
1.2.1.28
benzaldehyde dehydrogenase (NAD+)
1.2.1.29
aryl-aldehyde dehydrogenase
1.2.1.3
aldehyde dehydrogenase (NAD+)
1.2.1.67
vanillin dehydrogenase
1.2.1.7
benzaldehyde dehydrogenase (NADP+)
|
–
–
–
–
–
–
|
|
|
BRENDA:
BS258074
MetaCyc:
RXN-19745_WOP
|
|
|
|
3,4-dihydroxybenzoate + O2 <=> 2-hydroxy-5-carboxymuconate_semialdehyde + H+
|
1.13.11
1.13.11.15
3,4-dihydroxyphenylacetate 2,3-dioxygenase
|
–
–
|
M
|
|
BRENDA:
BS288977
MetaCyc:
RXN-10882
|
|
|
|
3,4-Dihydroxybenzaldehyde + NADP+ + H2O <=> 3,4-dihydroxybenzoate + NADPH + H+
|
1.2.1.67
vanillin dehydrogenase
|
–
|
M
|
|
BRENDA:
BS426964
MetaCyc:
RXN-19745
|
|
|
|
vanillic_acid + tetrahydrofolate <=> 3,4-dihydroxybenzoate + 5-methyltetrahydrofolate
|
2.1.1.341
vanillate/3-O-methylgallate O-demethylase
|
–
|
MK
|
|
BRENDA:
BR52053
KEGG:
R10136
MetaCyc:
RXN-2
|
|
|
|
3,4-dihydroxybenzoate + ATP + H+ <=> (3,4-dihydroxybenzoyl)adenylate + diphosphate
|
6.2.1.62
3,4-dihydroxybenzoate---[aryl-carrier protein] ligase
|
–
|
MK
|
|
BRENDA:
BR53043
KEGG:
R12576
MetaCyc:
RXN-10675
|
|
|
|
3,4-dihydroxybenzoate + NADH + O2 <=> Hydroxyquinol + NAD+ + CO2
|
1.13.11
1.14.13.64
4-hydroxybenzoate 1-hydroxylase
|
–
–
|
K
|
|
BRENDA:
BS3111
KEGG:
R01629
|
|
|
|
3,4-dihydroxybenzoate + NADPH + O2 <=> Hydroxyquinol + NADP+ + CO2
|
1.13.11
1.14.13.64
4-hydroxybenzoate 1-hydroxylase
|
–
–
|
K
|
|
BRENDA:
BS3124
KEGG:
R01630
|
|
|
|
4-Hydroxyisophthalate + O2 + NADPH + H+ <=> 3,4-dihydroxybenzoate + CO2 + NADP+ + H2O
|
1.14.13
|
–
|
MK
|
|
KEGG:
R11198
MetaCyc:
RXN-16974
|
|
|
|
3,4-dihydroxybenzoate <=> gallic_acid
|
not assigned
|
–
|
|
|
KEGG:
R01637
|
|
|
|
3,4-dihydroxybenzoate + NH3 <=> 4-Aminobenzoic_acid + O2 + 2 H+
|
1.14.12
|
–
|
K
|
|
KEGG:
R05280
|
|
|
|
vanillic_acid + cob(I)alamin <=> 3,4-dihydroxybenzoate + methylcobalamin
|
2.1.1
|
–
|
K
|
|
KEGG:
R07668
|
|
|
|
4-Hydroxyisophthalate + O2 + NADH + H+ <=> 3,4-dihydroxybenzoate + H2O + NAD+ + CO2
|
1.14.13
|
–
|
K
|
|
KEGG:
R11197
|
|
|
|
(1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + H2O + NAD+ <=> H+ + 3,4-dihydroxybenzoate + NADH + HCO3-
|
1.3.1.53
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
|
–
|
|
|
MetaCyc:
DCDPC-RXN
|
|
|
|
H+ + 4-hydroxyylaminobenzoate + H2O <=> 3,4-dihydroxybenzoate + NH3
|
4.3.3
|
–
|
M
|
|
MetaCyc:
R365-RXN
|
|
|
|
3-chlorobenzoate-cis-3,4-diol <=> 3,4-dihydroxybenzoate + Cl- + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-10424
|
|
|
|
2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + H2O <=> 2,4,6-Trihydroxybenzoate + 3,4-dihydroxybenzoate + H+
|
3.1.1
|
–
|
M
|
|
MetaCyc:
RXN-12531
|
|
|
|
3-Methoxybenzoate + reduced_flavodoxin + O2 <=> 3,4-dihydroxybenzoate + flavin + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
|
BRENDA:
BS427979
|
|
|
|
benzoate + reduced_flavodoxin + O2 <=> 3,4-dihydroxybenzoate + flavin + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
|
BRENDA:
BS428430
|
|
|
|
3-hydroxybenzoate + reduced_flavodoxin + O2 <=> 3,4-dihydroxybenzoate + flavin + H2O
|
1.14.13.23
3-hydroxybenzoate 4-monooxygenase
1.14.14.92
benzoate 4-monooxygenase
|
–
–
|
|
|
BRENDA:
BS288472
|
|
|
|
3,4-dihydroxybenzoate + O2 <=> (3,4-dioxocyclohexa-1,5-dien-1-yl)acetic_acid + H2O
|
1.14.18.1
tyrosinase
|
–
|
|
|
BRENDA:
BS353357
|
|
|
|
3,4-dihydroxybenzoyl-CoA + H2O <=> CoA + 3,4-dihydroxybenzoate
|
3.1.2.20
acyl-CoA hydrolase
3.1.2.28
1,4-dihydroxy-2-naphthoyl-CoA hydrolase
|
–
–
|
|
|
BRENDA:
BS403676
|
|
|
|
4-hydroxybenzoate + O2 + reduced_acceptor <=> 3,4-dihydroxybenzoate + H2O + A
|
1.14.18.1
tyrosinase
|
–
|
|
|
BRENDA:
BS353364
|
|
|
|
1-O-Protocatechuoyl-beta-D-glucose + H2O <=> 3,4-dihydroxybenzoate + D-glucose
|
3.1.1.20
tannase
|
–
|
|
|
BRENDA:
BS73167
|
|
|
|
S-adenosyl-L-methionine + 3,4-dihydroxybenzoate <=> S-adenosyl-L-homocysteine + vanillic_acid + Isovanillate
|
2.1.1.6
catechol O-methyltransferase
|
–
|
|
|
BRENDA:
BS456380
|
|
|
|
S-adenosyl-L-methionine + 3,4-dihydroxybenzoate <=> S-adenosyl-L-homocysteine + vanillic_acid
|
2.1.1.6
catechol O-methyltransferase
2.1.1.68
caffeate O-methyltransferase
|
–
–
|
|
|
BRENDA:
BS319839
|
|
|
|
3,4-dihydroxybenzoate + S-adenosyl-L-methionine <=> Isovanillate + S-adenosyl-L-homocysteine
|
2.1.1.6
catechol O-methyltransferase
|
–
|
|
|
BRENDA:
BS419954
|
|
|
|
4-coumaroyl-CoA + 3,4-dihydroxybenzoate <=> CoA + 3-O-(4-coumaroyl)oxy-4-hydroxybenzoate
|
2.3.1.133
shikimate O-hydroxycinnamoyltransferase
|
–
|
|
|
BRENDA:
BS435122
|
|
|
|
(3,4-Methylenedioxy)benzoate + NADH + O2 <=> 3,4-dihydroxybenzoate + NAD+ + H2O + formaldehyde
|
1.14.99.15
4-methoxybenzoate monooxygenase (O-demethylating)
|
–
|
|
|
BRENDA:
BS287948
|
|
|
|
Isovanillate + NADH + O2 <=> 3,4-dihydroxybenzoate + NAD+ + H2O + formaldehyde
|
1.14.13.82
vanillate monooxygenase
|
–
|
|
|
BRENDA:
BS386511-a
|
|
|
|
3,4-dihydroxybenzoate + NADH + O2 <=> 2,4,5-Trihydroxybenzoate + NAD+ + H2O
|
1.14.13.24
3-hydroxybenzoate 6-monooxygenase
|
–
|
|
|
BRENDA:
BS288467
|
|
|
|
3-hydroxybenzoate + NADH + O2 <=> 3,4-dihydroxybenzoate + NAD+ + H2O
|
1.14.13.23
3-hydroxybenzoate 4-monooxygenase
1.14.99.15
4-methoxybenzoate monooxygenase (O-demethylating)
|
–
–
|
|
|
BRENDA:
BS287954
|
|
|
|
syringic_acid + 2 tetrahydrofolate <=> 3,4-dihydroxybenzoate + 2 5-methyltetrahydrofolate
|
2.1.1.341
vanillate/3-O-methylgallate O-demethylase
|
–
|
|
|
BRENDA:
BS439920
|
|
|
|
4-hydroxybenzoate + O2 <=> 3,4-dihydroxybenzoate + H2O
|
1.1.1.24
quinate dehydrogenase
|
–
|
|
|
BRENDA:
BS187889
|
|
|
|
catechol + KHCO3 <=> 3,4-dihydroxybenzoate
|
4.1.1.63
protocatechuate decarboxylase
|
–
|
|
|
BRENDA:
BS416756
|
|
|
|
vanillic_acid + NADPH + O2 <=> 3,4-dihydroxybenzoate + NADP+ + H2O + formaldehyde
|
1.14.13.82
vanillate monooxygenase
|
–
|
|
|
BRENDA:
BS386759
|
|
|
|
Isovanillate + NADPH + O2 <=> 3,4-dihydroxybenzoate + NADP+ + H2O + formaldehyde
|
1.14.13.82
vanillate monooxygenase
|
–
|
|
|
BRENDA:
BS386511
|
|
|
|
3,4-dihydroxybenzoate + 2 NADPH + 2 Br- + 2 O2 + 2 H+ <=> 3,5-dibromobenzene-1,2-diol + 4-bromocatechol + 2 NADP+ + CO2 + 4 H2O
|
1.14.19.55
4-hydroxybenzoate brominase (decarboxylating)
|
–
|
|
|
BRENDA:
BS442828
|
|
|
|
4-hydroxybenzoate + NADPH + ferricyanide <=> 3,4-dihydroxybenzoate + NADP+ + ferrocyanide
|
1.14.13.2
4-hydroxybenzoate 3-monooxygenase
|
–
|
|
|
BRENDA:
BS257954
|
|
|
|
3,4-dihydroxybenzoate + NADP+ + H2O <=> 2-Pyrone-4,6-dicarboxylate + NADPH + H+
|
1.1.1.312
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
|
–
|
|
|
BRENDA:
BS389612
|
|
|
|
3,4-dihydroxybenzoate + NADPH + H+ + O2 <=> gallic_acid + NADP+ + H2O
|
1.14.13.2
4-hydroxybenzoate 3-monooxygenase
|
–
|
|
|
BRENDA:
BS440753
|
|
|
|
UDP-glucose + 3,4-dihydroxybenzoate <=> UDP + protocatechuyl-beta-D-glucose
|
2.4.1.136
gallate 1-beta-glucosyltransferase
|
–
|
|
|
BRENDA:
BS322062
|
|
|
|
ethyl_3,4-dihydroxybenzoate + H2O <=> ethanol + 3,4-dihydroxybenzoate
|
3.1.1.1
carboxylesterase
3.1.1.20
tannase
|
–
–
|
|
|
BRENDA:
BS363920
|
|
|
|
3,4-dihydroxybenzoate + O2 <=> 3,4-dioxocyclohexa-1,5-diene-1-carboxylic_acid + H2O
|
1.14.18.1
tyrosinase
|
–
|
|
|
BRENDA:
BS398207
|
|
|
|
3,4-dihydroxyphenylacetaldehyde + H2O + O2 <=> 3,4-dihydroxybenzoate + H2O2
|
1.2.3.1
aldehyde oxidase
|
–
|
|
|
SABIO-RK:
12030
|
|